ECG & Pulse Doppler Systems For Cardiovascular Research on Mice
Electronics Contract R&D For Medical, Scientific, & Industrial Instrumentation

 
 

Blood, Sweat, And Tears

(Detection of Free Hemoglobin and Glycerol in a Saline Solution

 

Surgimedics/TMP came to us with an interesting problem: They were developing a blood processing device that washes out glycerol from frozen blood in preparation for eventual human use. The decision to terminate the washing cycle is partly based on the amount of glycerol and free hemoglobin present in the exhaust (downstream) saline washing solution. The challenge was to measure the concentrations without contacting the fluid.

Indus suggested two novel ways to measure these parameters non-invasively, conducted feasibility studies to prove the concepts, developed electronics and software, fabricated sensors, and produced initial production quantities to meet a crucial deadline for the client all in a matter of 10 weeks.

 
The block diagram to the left shows the glycerol sensing technique based on measuring the speed of sound. It turns out that the speed of sound will vary with the percentage of glycerol in the saline solution. Free hemoglobin was estimated by measuring the absorption of blue light in the saline solution. When corrected for temperature and calibrated both sensors give accurate readings to within 2%.